state that water is the main component of blood and tissue fluid and relate the properties of water to its role in transport in mammals, limited to solvent action and high specific heat capacity

describe the role of red blood cells in transporting oxygen and carbon dioxide with reference to the roles of: • haemoglobin • carbonic anhydrase • the formation of haemoglobinic acid • the formation of carbaminohaemoglobin

explain the relationship between genes, proteins and phenotype with respect to the: • TYR gene, tyrosinase and albinism • HBB gene, haemoglobin and sickle cell anaemia • F8 gene, factor VIII and haemophilia • HTT gene, huntingtin and Huntington’s disease