explain the relationship between genes, proteins and phenotype with respect to the: • TYR gene, tyrosinase and albinism • HBB gene, haemoglobin and sickle cell anaemia • F8 gene, factor VIII and haemophilia • HTT gene, huntingtin and Huntington’s disease

relate the structure of haemoglobin to its function, including the importance of iron in the haem group

describe and explain the oxygen dissociation curve of adult haemoglobin