9700_s11_qp_23
A paper of Biology, 9700
Questions:
6
Year:
2011
Paper:
2
Variant:
3

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For Examiner’s Use In mammals, haemoglobin is used to transport oxygen and myoglobin is used to store oxygen in muscles. shows the oxygen dissociation curves for myoglobin, fetal haemoglobin and adult haemoglobin. percentage saturation with oxygen partial pressure of oxygen / kPa fetal haemoglobin adult haemoglobin myoglobin Name the cells in which haemoglobin is found. Use to determine the percentage saturation of myoglobin and adult haemoglobin when the partial pressure of oxygen is 3 kPa. myoglobin adult haemoglobin For Examiner’s Use There is a large difference between the percentage saturation of myoglobin and that of adult haemoglobin at low partial pressures of oxygen. Suggest reasons for this. Fetal haemoglobin has a different oxygen binding affinity to that of adult haemoglobin, as shown in . Normally, after birth, the production of the fetal form stops and the adult form is produced. In a rare condition known as Hereditary Persistence of Fetal Haemoglobin (HPFH), fetal haemoglobin continues to be produced well into adulthood in addition to adult haemoglobin. This condition, however, usually lacks any symptoms. Explain, with reference to , the significance of the difference in oxygen binding affinity between fetal and adult haemoglobin. Suggest why HPFH usually lacks symptoms. For Examiner’s Use Sketch on the dissociation curve you would expect for adult haemoglobin if the concentration of carbon dioxide is increased. percentage saturation of haemoglobin with oxygen partial pressure of oxygen / kPa adult haemoglobin
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