9700_s19_qp_22
A paper of Biology, 9700
Questions:
6
Year:
2019
Paper:
2
Variant:
2

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is a photomicrograph of human blood cells from a healthy individual who lives at sea level. The cells labelled C, D and E are white blood cells. C D E red blood cell Name cells C, D and E. C D E In humans, an increase in the white blood cell count can be associated with leukaemias and with infectious diseases, such as measles. Chronic lymphocytic leukaemia (CLL) is a type of cancer that starts in the bone marrow. In the early stages, many people with CLL feel well. The disease is sometimes diagnosed by chance during a routine blood analysis, when a high white blood cell count is noticed. Many of these white blood cells are only partially mature. Suggest why CLL starts in the bone marrow and not in any other location in the body. Explain why a high white blood cell count is a feature of measles and of CLL. measles CLL Most of the oxygen that enters the mammalian circulatory system is transported by red blood cells. Describe and explain the passage of oxygen across the cell surface membrane of the red blood cell. At a high altitude, the partial pressure of oxygen in the atmosphere is lower than at sea level. If a person travels from low altitude to high altitude and remains there for a few weeks, the red blood cell count increases. Explain why the body needs to respond to high altitude by increasing the number of red blood cells. Polypeptide synthesis occurs before a red blood cell is released into the circulation. The HBB gene codes for the β-globin polypeptide of haemoglobin. There are two alleles of HBB, known as HbA and HbS. Describe the difference between the HbA allele and the HbS allele and state how this difference affects: • the β-globin polypeptide • the haemoglobin molecule.
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The bacterium Vibrio cholerae is the causative organism of the infectious disease cholera. V. cholerae has structural features typical of all bacterial cells. It also has a flagellum for movement. is an outline drawing of V. cholerae. Complete by drawing and labelling the structures found in V. cholerae. flagellum The World Health Organization (WHO) collects data about cholera from the 194 countries that are members of the World Health Assembly (WHA). In 2015: • there were cases of cholera in 42 of the member countries of the WHA • the total number of cases of cholera reported was 172 454 • there were deaths as a result of cholera in 23 of these countries • the total number of deaths from cholera reported was 1304. The case fatality rate for cholera is the proportion of cases of cholera that results in death within a particular time period. A country with cases of cholera that are properly treated should have a case fatality rate of less than 1%. Calculate the case fatality rate for the 42 member countries of the WHA for 2015. Give your answer to the nearest 0.1%. case fatality rate = % Many of the 23 countries reporting deaths from cholera in 2015 had a case fatality rate of less than 1%. However, two of the 23 countries had case fatality rates greater than 5%. Suggest two explanations for the higher case fatality rate in these two countries. In 2010, the country of Haiti experienced a major earthquake. This led to an outbreak of cholera. Explain why an earthquake may lead to a cholera outbreak. shows data about cholera collected by WHO over a period of 8 years, from 2008 to 2015. These data include: • the total number of cases of cholera for each year • the number of countries in each year that had cases of cholera. 100 000 200 000 300 000 400 000 500 000 600 000 700 000 number of countries number of cases year Key number of cases number of countries Comment on the trends shown in .
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