9700_w22_qp_23
A paper of Biology, 9700
Questions:
6
Year:
2022
Paper:
2
Variant:
3
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1
During translation, a polypeptide is synthesised when amino acids are added to a growing chain of amino acids. shows part of a growing chain of amino acids and the amino acid cysteine. chain of amino acids cysteine C C + O OH C C CH2 SH N O H H H OH Complete by showing the formation of the bond between cysteine and the growing chain of amino acids in the process of translation. State the name of the covalent bond that forms when cysteine is added to the growing chain of amino acids. State the organelle where the reaction shown in takes place. is a ribbon diagram showing the three-dimensional structure of a protein from the bacterium Streptococcus. Describe the secondary structure of the protein shown in . Explain why the protein shown in has tertiary structure, but not quaternary structure. An analysis of the amino acid composition of the protein in showed that it does not contain any cysteine residues. Explain how the three-dimensional structure of the protein shown in is held in place.
6. Nucleic acids and protein synthesis  →  6.2. Protein synthesis
2. Biological molecules  →  2.3. Proteins
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2
is a scanning electron micrograph showing a macrophage engulfing some bacteria. Describe how macrophages engulf bacteria. Explain the functions of lysosomes in cells such as macrophages. shows the reported number of new cases of tuberculosis (TB) in the USA and the number of new cases per 100 000 of the population of the USA between 1993 and 2018. number of new cases per 100 000 population number of new cases per 100 000 population number of new cases Key number of new cases 30 000 25 000 20 000 15 000 10 000 year Calculate the percentage change in the number of new cases of TB in the USA between 1993 and 2018. Show all your working. answer % Use to describe the trend in the number of new cases of TB in the USA between 1993 and 2018. Suggest an advantage of calculating the number of new cases per 100 000 each year in the prevention and control of TB across the world. TB is endemic (always present) in many populations across the world and many countries have high numbers of cases. State two reasons why it is difficult to reduce the number of cases of TB across the world.
10. Infectious diseases  →  10.1. Infectious diseases
10. Infectious diseases  →  10.2. Antibiotics
18. Classification, biodiversity and conservation  →  18.2. Biodiversity
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3
Explain how water moves up xylem vessels in the trunks of trees. Cavitation is the formation of air-filled spaces inside the columns of water in xylem vessels in trees. These air-filled spaces form more often when there are high rates of movement of water in xylem vessels. When an air-filled space forms in a xylem vessel, a noise is made that can be detected as a ‘click’ by a sensor placed close to the xylem vessels in the trunk of a tree. Students investigated the relationship between two environmental factors and the rate of cavitation in a Scots pine tree, Pinus sylvestris, over a 50-hour period. The two factors they investigated were: • photosynthetically active radiation (PAR), which is the light energy available to plants that they absorb and use in photosynthesis • wind speed. The cavitation rate was estimated by recording the number of clicks detected by the sensor. The results are shown in . Suggest the conclusions that can be made with reference to the data in .
7. Transport in plants  →  7.2. Transport mechanisms
4. Cell membranes and transport  →  4.2. Movement into and out of cells
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4
The early development of an animal involves divisions of the zygote and daughter cells by mitosis to form an embryo consisting of genetically identical cells. shows several cells at various stages of the cell cycle in an embryo of whitefish, Coregonus artedi. magnification ×1200 microtubules A C B Name the stage of mitosis in cell A and in cell B, shown in . A B shows microtubules in the cells that are dividing. Describe the role of microtubules in mitosis. State what happens in cell C, shown in , until two new cells are formed. The cells produced in the developing whitefish are genetically identical. Identify and explain two events that occur during the cell cycle that lead to daughter cells being genetically identical.
16. Inheritance  →  16.1. Passage of information from parents to offspring
5. The mitotic cell cycle  →  5.1. Replication and division of nuclei and cells
5. The mitotic cell cycle  →  5.2. Chromosome behaviour in mitosis
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5
Cathelicidin LL-37 is a cell signalling compound that stimulates many different cells in humans. One role of cathelicidin LL-37 is stimulating the production of endothelial cells in the formation of capillaries during wound healing. Explain how it is possible for many different cell types to respond to the same cell signalling compound. Describe the appearance of the endothelial cells of a capillary. Cathelicidin LL-37 is a protein composed of 37 amino acids. Table 5.1 shows: • the sequence of the first 10 amino acids in the primary structure of cathelicidin LL-37 • DNA triplets in the non-transcribed strand in the gene that codes for the first 10 amino acids in the primary structure of cathelicidin LL-37. Table 5.1 amino acid position amino acid leu leu gly asp phe phe arg lys ser lys DNA triplet CTG CTG GGT GAT TTC TTC CGG AAA TCT AAA Table 5.2 shows the triplets of bases in DNA and the amino acids for which they code. Table 5.2 first base second base third base cys stop stop his gln asp lys asp ala val met ile ile leu leu phe thr pro ser glu try tyr arg ser arg gly T T C A G C A G T C A G T C A G T C A G T C A G TTT TCT TAT TGT TCC TAC TGC TCA TAA TGA TCG TAG TGG CCT CAT CGT CCC CAC CGC CCA CAA CGA CCG CAG CGG ACT AAT AGT ACC AAC AGC ACA AAA AGA ACG AAG AGG GCT GAT GGT GCC GAC GGC GCA GAA GGA GCG GAG GGG TTC TTA TTG CTT CTC CTA CTG ATT ATC ATA ATG GTT GTC GTA GTG Mutations of DNA base sequences in a gene can affect the primary structure of proteins. Use the information in Table 5.1 and Table 5.2 to suggest the effect on the primary structure of cathelicidin LL-37 of: the substitution of the base T with the base A in the middle of the triplet at position 5 the deletion of base T in the triplet at position 2 the insertion of base G between bases G and T in the triplet at position 3. The genetic code is described as universal. Explain why the genetic code is described as universal. Use Table 5.2 to explain why some mutations have no effect on the primary structure of a protein.
4. Cell membranes and transport  →  4.1. Fluid mosaic membranes
6. Nucleic acids and protein synthesis  →  6.2. Protein synthesis
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6
shows some of the events that occur when a red blood cell flows through a capillary in the lungs. Cl – HCO3 – HCO3 – + H+ H2CO3 CO2 + H2O CO2 O2 HbO2 + H+ X + O2 carbonic anhydrase plasma red blood cell State why there are transport proteins in the membranes of red blood cells to allow the movement of hydrogencarbonate ions (HCO3 –) and chloride ions (Cl –). shows that chloride ions move out of the red blood cells. Explain why this movement is necessary when red blood cells flow through capillaries in the lungs. State why carbon dioxide molecules diffuse from the red blood cells into the plasma. State the name of the compound indicated by X.
8. Transport in mammals  →  8.2. Transport of oxygen and carbon dioxide
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