0610_s22_qp_43
A paper of Biology, 0610
Questions:
6
Year:
2022
Paper:
4
Variant:
3

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Red blood cells contain the protein haemoglobin. State the names of the four chemical elements that are found in all proteins. State the role of haemoglobin. shows a photomicrograph of some red blood cells from a person with sickle cell anaemia. Abnormal red blood cells occur because of a mutation in the gene for haemoglobin. abnormal red blood cell Suggest how the shape of the abnormal red blood cell shown in will affect blood flow. The allele for the normal form of haemoglobin is HbA. The allele for the abnormal form of haemoglobin is HbS. Draw a genetic diagram to determine the probability of two heterozygous parents having a child who does not have the HbS allele. parental phenotypes x parental genotypes x gametes , x , offspring genotypes probability of offspring not having the HbS allele and are maps showing some of the different regions in a country. Scientists studied the distribution of the HbS allele in the country. shows the estimated frequency of the allele within the population. shows the estimated number of babies born with sickle cell anaemia in each region. A C B low high estimated frequency of the HbS allele in the population A C B low medium high estimated number of babies born with sickle cell anaemia The scientists made a statement: ‘There is a relationship between the frequency of the HbS allele and the number of babies born with sickle cell anaemia in regions A, B and C.’ Using the information in and , discuss the evidence for and against this statement for regions A, B and C only. Suggest how the scientists would identify the presence of the HbS allele in tissue samples. Mutations are always inherited in single-celled organisms that reproduce asexually but are not always inherited in organisms that reproduce sexually. Explain why.
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