1. Cell structure
A section of Biology, 9700
Listing 10 of 513 questions
People who become infected with human immunodeficiency virus (Hare at risk of developing HIV/AIDs, particularly if antiretroviral therapy (ART) is not available. In people infected with HIV, the use of ART also helps to reduce transmission of the virus to uninfected people. Outline two control methods, other than ART, that can be used to reduce the transmission of HIV. In people with HIV/AIDs, a serious lung disease known as pneumocystis pneumonia can result from infection by an opportunistic pathogen known as Pneumocystis jirovecii. shows P. jirovecii cells in one stage of their life cycle, as seen using a light microscope at a magnification of ×600. 0.4 μm Define magnification. shows that P. jirovecii is a unicellular organism. Although the cells of many species of bacteria are the same size as those of P. jirovecii, research concluded that the organism is a eukaryote and is not a bacterium. In 1988, analysis of ribosomal RNA (rRNA) resulted in P. jirovecii being classified as a fungus. Studies of the structure of P. jirovecii have identified that the cell wall is made of polysaccharides such as chitin and 1,3‑β‑D‑glucan. Explain why this feature helped scientists to confirm that P. jirovecii is not a bacterium. Scientists have identified other features of the cell structure of P. jirovecii. Some of these are listed in Table 2.1. Complete each row of Table 2.1 so that the table shows: • four structural features identified in P. jirovecii • one function for each structural feature • whether the structural feature is present (✓) or absent (✗) in bacterial cells. Table 2.1 structural feature of P. jirovecii function present (✓) or absent (✗) in bacterial cells ribosomes protein synthesis smooth endoplasmic reticulum Golgi body modification of proteins and lipids aerobic respiration P. jirovecii can adhere to squamous epithelial cells of the alveoli and to the network of fibrous proteins that support the alveolar wall, known as the extracellular matrix (ECM). Examples of proteins in the ECM are elastin and collagen. Adhesion of P. jirovecii to alveolar epithelial cells and the ECM stimulates the growth of its population. Cell surface glycoproteins known as gpA glycoproteins are essential in allowing P. jirovecii cells to adhere to alveolar epithelial cells and ECM proteins. Suggest how a gpA glycoprotein is able to adhere to alveolar epithelial cells and ECM proteins. One consequence of the pneumonia that results from P. jirovecii infection is a decrease in the quantity of oxygen that is delivered to body tissues. Explain why a severe P. jirovecii infection results in a decrease in the quantity of oxygen that is delivered to body tissues. P. jirovecii produces an enzyme known as 1,3‑β‑D‑glucan synthase. The enzyme catalyses the synthesis of 1,3‑β‑D‑glucan. The therapeutic drug caspofungin is a non‑competitive inhibitor of 1,3‑β‑D‑glucan synthase. With reference to the mechanism of action of caspofungin, explain how the drug may be useful to treat cases of pneumonia caused by P. jirovecii.
9700_w24_qp_22
THEORY
2024
Paper 2, Variant 2
Questions Discovered
513