9700_w14_qp_22
A paper of Biology, 9700
Questions:
6
Year:
2014
Paper:
2
Variant:
2

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I n mammals, oxygen is transported by red blood cells in a system that is described as a closed double circulation. The majority of oxygen molecules are transported as oxyhaemoglobin. At the respiring tissues, oxygen dissociates from haemoglobin and diffuses to the surrounding cells. Explain what is meant by a closed double circulation. is a diagram that highlights the tertiary and quaternary structure of a haemoglobin molecule. haem groups At high altitudes, the partial pressure of inspired oxygen is considerably lower than at sea level. This means that the partial pressure of oxygen in the blood is also much lower at high altitudes than at sea level. is an oxygen dissociation curve of adult oxyhaemoglobin. partial pressure of oxygen / kPa percentage saturation of haemoglobin With reference to , calculate the difference in percentage saturation of haemoglobin at sea level, where the partial pressure of oxygen is 13.0 kPa, and at a higher altitude, where the partial pressure of oxygen is 6.2 kPa. Show your working. answer % After spending time at altitude, a person can become acclimatised. One feature of acclimatisation is an increase in the red blood cell count. Explain the importance of the increase in the red blood cell count. Before acclimatisation can occur, some people develop a condition known as acute mountain sickness when they travel to high altitude areas. Acetazolamide is a non-competitive enzyme inhibitor that is used as a drug to prevent and treat acute mountain sickness. Explain the effects of a non-competitive inhibitor on the rate of enzyme activity. Tobacco smoking can have an effect on the transport of oxygen by haemoglobin. shows oxygen dissociation curves with and without the presence of carbon monoxide (CO). partial pressure of oxygen / kPa percentage saturation of haemoglobin no CO (non-smoker) 20% CO (heavy smoker) With reference to , describe the effect of carbon monoxide on the cardiovascular system.
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